The article explores the factors that facilitate or hinder employees’ adjustment when moving from a conventional office-based environment to a virtual work environment, whether situated distantly or at home.1Screen reader users, this is the main argument/aim. The article suggests that structural factors (such as work independence and clear evaluation criteria) and relational factors (such as feeling of trust in colleagues and management, and a sense of connectedness to the company) are key facilitators of successful adjustment.2Screen reader users, this is supporting argument. The researchers also explore aspects such as age, gender and experience of virtual work, as moderators of the key indicators.3Screen reader users, this is a supporting argument.